LEPTIN and GHRELIN are appetite regulating hormones in the body. Leptin usually is produced after eating, it is the hormone that tells you when you are full. On the other hand, ghrelin is the hunger hormone, it is produced when you are hungry.

There is a condition called Alcohol Use Disorder(AUD) in which these hormones are grossly implicated.

In a study carried out, it was shown that infusion of intravenous Ghrelin increased the craving for juice and alcohol and decreased the serum leptin levels. Infusion of leptin acted to curb alcohol cravings but did not affect the urge to drink juice. So in line with this study, a ghrelin antagonist is currently being developed as a potential treatment for AUD. Although this research does not have any ongoing clinical implications, it is at the cutting edge of drug development for Alcohol addiction.

On a final note, alcohol addiction is something the society frowns at. Physicians are trying very hard to curb this social ill.



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Cynthia Isuekebhor