Hello colleagues, lets do some brain work….
A 20-year-old female presents to your office for routine well-woman examination. She has a history of acne, for which she takes minocycline and isotretinoin on a daily basis. She also has a history of epilepsy that is well controlled on valproic acid. She also takes a combined oral contraceptive birth control pill norethindone acetate and ethinyl estradiol.
She is a non smoker but drinks alcohol on a daily basis. She is concerned about the effectiveness of her birth control pill, given all the medications she takes. She is particularly worried about the effects of her medications on her developing fetus in the event of an unintended pregnancy.
Which of the following drugs has the lowest potential to cause birth defects: Alcohol, Isotretinoin, Tetracyclines, Progesterone, Valproic acid?
The answer is PROGESTERONE.
- Progesterone has been indicated for multiple birth defects, but controlled studies have failed to demonstrate significant association with increased risk. Patients who have become pregnant while on birth control pills should be reassured that the incidence of birth defects is no higher for them than in the general population.
- All other drugs produce congenital anomalies and should never be used during pregnancy.
REFERENCE: MCGRAW HILLS USMLE EASY.COM