A BIOMARKER FOR MULTIPLE-SYSTEM ATROPHY?

Patients with multiple-system atrophy but no visual symptoms exhibit a progressive thinning of the retinal nerve fiber layer and, to a lesser extent, of the macular ganglion cell complex.

MSA is caused by a deposition of misfolded alpha-synuclein primarily in the Oligodendroglia. In contrast, in patients with Parkinson’s disease, the alpha-synuclien is on the neurons.

This creates an understanding of what differentiates MSA from Parkinson’s disease, the way that the retina is affected early is different among these diseases.

REFERENCE: DECEMBER ISSUE OF MOVEMENT DISORDERS.

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Cynthia Isuekebhor